Dr. Anne Parle-McDermott, Dublin City University:
“Applying molecular genetics expertise to biosensing questions”
This seminar will describe both a career and a research interest journey. Having worked with nucleic acids for over 25 years it has been interesting to apply my knowledge and expertise of molecular genetics to a range of research questions. The main interest of my group has been to understand the role of the essential B vitamin, folate, for human health with a particular interest in the prevention of Neural Tube Defects. Folate is a key supplier of the One Carbon Metabolism (OCM) pathway which is required for numerous essential cellular reactions including the methylation of DNA/proteins and supplying the one carbons necessary for DNA synthesis. More recently, my group has branched out to the examination of environmental DNA which is the DNA that is left behind by a given species within their habitat. We were the first to apply CRISPR-Cas technology for single species detection from environmental DNA enabling us to further develop this approach to biosensors to detect any target species. Having two quite different strands to my research has proven to be fruitful and interesting with similar molecular techniques and know-how underpinning both aspects and illustrating the value of addressing a diverse range of research questions.
Anne Parle-McDermott is Professor in Genetics at the School of Biotechnology at Dublin City University (DCU), Ireland. She has worked in Molecular Biology for over 25 years having learned the fundamentals while studying at Trinity College Dublin, including being part of the European Yeast Sequencing Project. She earned her doctorate in Molecular Cancer at the Royal College of Surgeons in Ireland and returned to Trinity as a Postdoctoral Fellow where she was introduced to folate research and understanding its role in human health. She progressed to a temporary lecturing position at Trinity before moving to DCU in 2006 where she attained tenure in 2009. Anne has held numerous roles in DCU including Head of School from 2018 to 2020. Her research interests are in the complementary areas of functional genetics as it relates to human health and the application of DNA-based methodologies for diagnostics and biosensor development. She teaches a range of modules on Eukaryotic genetics and genomics. Her research group is currently supported by grants from Science Foundation Ireland, Irish Research Council, the Irish Government North-South Programme and the EU. This academic year sees Anne on Sabbatical and she’s at @ UMaine SBE until the end of November.
hosted by Mike Kinnison